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Author: Admin | 2025-04-28
Recovery between beats).Selective serotonin & norepinephrine inhibitors (SNRIs)SNRIs block your nerve synapses from taking up both serotonin and norepinephrine. Different SNRIs vary in how well they block each of these neurotransmitters. For instance, some work more on serotonin than on norepinephrine, and others work more on norepinephrine. Examples of SNRIs and the neurotransmitters they target more include:Desvenlafaxine (Khedezla) — works more on serotonin than on norepinephrineDuloxetine (Cymbalta) — works more on serotonin than on norepinephrineLevomilnacipran (Fetzima) — works more on norepinephrine than on serotoninMilnacipran (Savella) — works more on norepinephrine than on serotoninVenlafaxine (Effexor) — works more on serotonin than on norepinephrineThe most common side effects of SNRIs include high blood pressure, headache, excessive sweating, and bone resorption or loss. Novel serotonergic drugs (serotonin modulators)Like SSRIs, these antidepressants block your nerve synapses from taking up serotonin. But they do this by binding to different proteins on your cells than SSRIs do. Each of these serotonin modulators works on slightly different proteins or sets of proteins on the cells of your nerve synapses. So, each has a slightly different way of working and a slightly different set of side effects.Examples of serotonin modulators include:NefazodoneTrazodoneVilazodone (Viibryd)Vortioxetine (Trentellix)The most common side effects reported for each are as follows:Nefazodone: Liver toxicity, including the risk for acute hepatitis and liver failureTrazodone: Drowsiness and a prolonged erection lasting more than four hoursVilazodone (Viibryd): DiarrheaVortioxetine (Trentellix): Nausea Tricyclic antidepressantsLike SNRIs, tricyclic antidepressants block both serotonin and norepinephrine, but at a different point in the process. Tricyclic antidepressants
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