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Author: Admin | 2025-04-28
Orally in two or three divided doses as indicated in Table 1. In pediatric patients, the recommended dosing regimen is dependent upon body weight. Based on clinical response and tolerability, dosage may be increased, approximately weekly.Table 1. Recommended Dosage for Adults and Pediatric Patients 1 Month and OlderAge and Body WeightRecommended Initial DosageRecommended Maximum DosageFrequency of AdministrationAdults (17 years and older)150 mg/day600 mg/day2 or 3 divided dosesPediatric patients weighing 30 kg or more2.5 mg/kg/day10 mg/kg/day(not to exceed 600 mg/day)2 or 3 divided dosesPediatric patients weighing less than 30 kg3.5 mg/kg/day14 mg/kg/day1 month to less than 4 years of age:3 divided doses4 years of age and older:2 or 3 divided dosesBoth the efficacy and adverse event profiles of LYRICA have been shown to be dose-related.The effect of dose escalation rate on the tolerability of LYRICA has not been formally studied.The efficacy of adjunctive LYRICA in patients taking gabapentin has not been evaluated in controlled trials. Consequently, dosing recommendations for the use of LYRICA with gabapentin cannot be offered. Management of Fibromyalgia in AdultsThe recommended dose of LYRICA for fibromyalgia is 300 to 450 mg/day. Begin dosing at 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day). Although LYRICA was also studied at 600 mg/day, there is no evidence that this dose confers additional benefit and this dose was less well tolerated. In view of the dose‑dependent adverse reactions, treatment with doses above 450 mg/day is not recommended. Neuropathic Pain Associated with Spinal Cord Injury in AdultsThe recommended dose range of LYRICA for the treatment of neuropathic pain associated with spinal cord injury is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience
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