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Author: Admin | 2025-04-28
As autoimmune diseases and cancer. It is also prescribed to relief the respiratory complications caused by COVID‐19 infection. It can cause some health complications such as GIT ulcers, so it should be co‐administered with proton pump inhibitors such as esomeprazole to prevent the risk of ulcers. Therefore this work aims to develop an ecofriendly and sensitive TLC method for simultaneous determination of esomeprazole and prednisolone in their binary mixture and spiked human plasma. The separation was performed using a mixture of ethyl acetate: methanol: ammonia (9.5: 0.5: 0.1, by volume) as eluting system with UV scanning at 245 nm. Dapoxetine was used as internal standard to correct the variation during sampling. The resulting Rf values for plasma, esomeprazole, prednisolone and dapoxetine were 0.03, 0.51, 0.72 and 0.85, respectively. Four greenness assessment tools including national environmental method index, eco‐scale assessments, analytical greenness metric approach (AGREE), and green analytical procedure index were used to evaluate the greenness characters of the proposed method to the environment and the results were accepted and satisfying. Validation parameters were checked according to US‐FDA guidelines to achieve the international requirements for bioanalytical method validation and the results were within the accepted ranges.... These methods include potentiometry 15 and chromatographyx [16][17][18][19] . Several methods have been reported for analysis of DAP in pharmaceutical dosage forms or in biological fluids; these methods include spectrophotometry 20 and chromatography [21][22] . ... Hesham SalemBasma E Abdel AzizTwo simple, rapid and novel sensitive fluorimetric and spectrophotometric methods were investigated for the assay of sildenafil citrate (SIL), dapoxetine (DAP), vardenafil (VAD) and tadalafil (TAD) using gold nanoparticles (Au NPs). On the spectrofluorimetric method, gold nanoparticles were used as a fluorescence probe. The addition of drugs to Au-NPs solution caused considerable quenching of the emission band of Au-NPs, which was likely due to the
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