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Author: Admin | 2025-04-28
Pain, including painful polyneuropathy and spinal cord injury pain, gabapentin was shown to be safe and effective IASP [Finnerup 2015]. Data from meta-analyses support the use of IR gabapentin for reducing pain by more than 50% in diabetic neuropathy Moore 2014, Rudroju 2013. Data from a limited number of clinical trials support the use of ER gabapentin in reducing pain by more than 50% and improving sleep in diabetic neuropathy Sandercock 2009, Sandercock 2012. A meta-analysis of trials evaluating the treatment of trigeminal neuralgia supports the use of gabapentin in the treatment of trigeminal neuralgia Yuan 2016.Based on guidelines from the International Association for the Study of Pain (IASP), European Federation of Neurological Societies (EFNS), and Society of Critical Care Medicine (SCCM), gabapentin is effective and recommended for the management of peripheral neuropathy EFNS [Attal 2010], IASP [Finnerup 2015], SCCM [Devlin 2018]). Based on guidelines from the EFNS, IASP, and National Institute for Health and Care Excellence (NICE), gabapentin is effective and recommended as first-line therapy, supported by strong evidence, in the management of diabetic neuropathy EFNS [Attal 2010], IASP [Finnerup 2015], NICE 2013. The IASP guidelines recommend both immediate- and extended-release gabapentin IASP [Finnerup 2015]. In contrast, a guideline from the American Academy of Neurology (AAN), American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation states that gabapentin is probably effective and should be considered an alternative treatment for painful diabetic neuropathy based on limited benefit in 2 controlled trials AAN [Bril 2011].
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