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Author: Admin | 2025-04-28
Clinical practice, hypertension, in some cases severe, requiring acute treatment, has been reported in patients receiving bupropion alone and in combination with nicotine replacement therapy. These events have been observed in both patients with and without evidence of preexisting hypertension.Some investigators have suggested that bupropion therapy may be 10 to 100 times less likely to induce conduction problems than tricyclic antidepressants.[Ref]OtherCommon (1% to 10%): Accidental injury, asthenia, auditory disturbance, chills, cutaneous temperature disturbance, fever, nonspecific fever, pain, temperature disturbance, tinnitusUncommon (0.1% to 1%): Inguinal hernia, nonspecific painRare (0.01% to 0.1%): Malaise, overdosePostmarketing reports: Deafness[Ref]GenitourinaryCommon (1% to 10%): Decrease in sexual function, dysmenorrhea, impotence, menstrual complaints, nocturia, urinary frequency, urinary tract infection, urinary urgency, vaginal hemorrhageUncommon (0.1% to 1%): Painful erection, polyuria, prostate disorder, retarded ejaculation, testicular swelling, vaginal irritationRare (0.01% to 0.1%): Enuresis, urinary incontinence, urinary retentionPostmarketing reports: Abnormal ejaculation, dyspareunia, dysuria, menopause, prostate disorder, salpingitis, urinary tract disorder, vaginitis[Ref]One study in which 150 patients received the sustained released form of bupropion (the active ingredient contained in Wellbutrin) reported the incidence of orgasm dysfunction at 8% in patients receiving a 300 mg daily dose and 10% in patients receiving a 400 mg daily dose.Among antidepressants, bupropion may be associated with the lowest incidence of sexual dysfunction (i.e., impotence, abnormal ejaculation, changes in libido).[Ref]MusculoskeletalCommon (1% to 10%): Arthralgia, arthritis, myalgia, neck pain, pain in extremity, twitch/twitchingUncommon (0.1% to 1%): Leg crampsPostmarketing reports: Muscle rigidity, muscle weakness, musculoskeletal chest pain, rhabdomyolysis[Ref]HypersensitivityCommon (1% to 10%): Allergic reaction, hypersensitivity reactionsUncommon (0.1% to 1%): Fever
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