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Author: Admin | 2025-04-28
Package insert / product labelGeneric name: morphine sulfateDosage form: oral solution, concentrateDrug class: Opioids (narcotic analgesics) 1. Indications and Usage for Morphine Sulfate Solution, Concentrate Morphine Sulfate Oral Solution 100 mg per 5 mL (20 mg per mL) is an opioid analgesic indicated for the management of moderate to severe acute and chronic pain in opioid-tolerant patients. Morphine Sulfate Oral Solution 100 mg per 5 mL (20 mg per mL) may cause fatal respiratory depression when administered to patients not previously exposed to opioids. Patients considered to be opioid tolerant are those who are taking at least 60 mg oral morphine sulfate per day, or at least 30 mg of oral oxycodone hydrochloride per day, or at least 12 mg hydromorphone hydrochloride per day, or an equianalgesic dose of another opioid, for a week or longer. 2. Morphine Sulfate Solution, Concentrate Dosage and Administration Morphine Sulfate Oral Solution is available in multiple concentrations. Take care when prescribing and administering Morphine Sulfate Oral Solution 100 mg per 5 mL (20 mg per mL) to avoid dosing errors due to confusion between different concentrations and between mg and mL, which could result in accidental overdose and death. Take care to ensure the proper dose is communicated and dispensed. When writing prescriptions, include both the total dose in mg and the total dose in volume. Always use the enclosed calibrated oral syringe when administering Morphine Sulfate Oral Solution 100 mg per 5 mL (20 mg per mL) to ensure the dose is measured and administered accurately. Selection of patients for treatment with morphine sulfate should be governed by the same principles that apply to the use of similar opioid analgesics. Individualize treatment in every case, using non-opioid analgesics, opioids on an as needed basis and/or combination products, and chronic opioid therapy in a progressive plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality, and the American Pain Society. 2.1 Individualization of Dosage As with any opioid drug product, adjust the dosing regimen for each patient individually, taking into account the patient’s prior analgesic
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