Allopurinol toxicity

☑️@allopurinol_toxicity · 2604 subscribers · Content 18+ 🔞
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Actual: Treatment In Allopurinol Toxicity Support: Management Of Mild To Moderate Toxicity : Treatment is symptomatic.
4.5 rating 2025-04-25
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This is a case series of allopurinol-induced toxic epidermal necrolysis. Revisiting the indications of using allopurinol in asymptomatic hyperuricemia and a

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Allopurinol. Mechanism : Allopurinol acts on purine catabolism. It reduces the Thiazide Diuretics: Enhancement of allopurinol toxicity in some patients.

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allopurinol increases toxicity of cyclophosphamide by decreasing metabolism. Use Caution/Monitor. dichlorphenamide. dichlorphenamide and allopurinol both decrease serum potassium. Use Caution/Monitor. dichlorphenamide, allopurinol. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely.

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Use Caution/Monitor. allopurinol. allopurinol decreases toxicity of amoxicillin by Other (see comment). Use Caution/Monitor. Comment: Allopurinol may

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allopurinol does not indicated that allopurinol would not be expected to cause embryotoxicity without also causing maternal toxicity.

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Colchicine has a very narrow therapeutic-toxic window and is extremely toxic in overdose. allopurinol or for whom allopurinol is contraindicated; MHRA advice

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Pegloticase: Allopurinol may enhance the adverse/toxic effect of Pegloticase. Specifically, Allopurinol may blunt increases in serum urate that would signal an increased risk of anaphylaxis and infusion reactions. Avoid combination. Riluzole: Allopurinol may enhance the adverse/toxic effect of Riluzole.

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uted to increased allopurinol toxicity were reviewed; a causal mechanism or in the management of an overdose of Allopurinol for Injection is unknown.

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Allopurinol - Toxicity Data: Oral TDLO (rat): 10 mg/kg; Oral Hazard Class: Toxic Solid, Organic, N.O.S. (Allopurinol). ICAO/IATA

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