Are platinum drugs renally cleared

European officials cleared the drug for use in combination with certain platinum-based chemotherapy. At a median follow-up of 17.3 months, the

No significant relationships exist between the renal clearance of either free platinum or cisplatin and creatinine clearance. Although small amounts of platinum are present in the bile and large intestine after administration of cisplatin, the fecal excretion of platinum appears to be insignificant.

The other one important aspect of platinum resistance is that oxaliplatin is the only platinum drug recommended for platinum resistance current .The aim is to choose the appropriate platinum drugs used for chemotherapy, which could help to reduce adverse drug reactions in important target organs and reduce the occurrence of platinum resistance

by Y Soma 2024 Cited by 1Oxaliplatin is associated with less frequent renal dysfunction than other conventional platinum-based drugs such as cisplatin [3]. Despite that

Platinum agents, Cisplatin; Carboplatin Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function.

Eliminated principally by renal excretion; renal clearance of ultrafilterable platinum appears to be directly proportional to GFR. Following

For renally excreted drugs with a narrow therapeutic index, the total daily Cytotoxics: increased risk with platinum compounds of nephrotoxicity

Intact cisplatin accounts for the majority of platinum excreted in the urine within one hour of administration. Renally excreted drugs. Literature data

Newer platinum agents such as this medication is not renally cleared and does not require dose adjustments in patients with renal insufficiency. Bortezomib should be given after dialysis in