Aldosterone agonist drugs

Primary aldosteronism, caused by autonomous secretion of aldosterone by the adrenals, is estimated to account for at least 5% of hypertension cases. Hypertension explains the considerable cardiovascular morbidity caused by aldosteronism only partly, calling for specific anti-aldosterone drugs. The p

Drug Mechanism Classes Adenosine receptor agonists Aldosterone-receptor antagonists Alpha-adrenoceptor agonists (alpha-agonists) Alpha-adrenoceptor

Drug, Drug Description. Spironolactone, An aldosterone receptor antagonist used to treat edema, hypertension, heart failure, and aldosteronism.

The drug spironolactone inhibits the effects of aldosterone by competitively binding to the aldosterone receptor in target cells; this drug is most commonly

Aldosterone Receptor Antagonists (ARAs) are a class of drugs that are used to inhibit the action of aldosterone, a hormone that regulates sodium

There are two types of potassium-sparing diuretics: aldosterone antagonists or drugs acting independently of aldosterone. Spironolactone and eplerenone are aldosterone antagonists, thereby inhibiting Na reabsorption and K loss through the blockade of aldosterone receptors in the DCT; these drugs are secreted from the peritubular capillaries.

Thus, spironolactone and eplerenone will block the adverse effects of the MR, irrespective of whether the MR agonist is aldosterone or cortisol. On the other hand, aldosterone synthase inhibitors will only block the MR that is being stimulated by aldosterone, thus leaving unaffected any consequences of MR stimulation by cortisol.

There are two types of potassium-sparing diuretics: aldosterone antagonists or drugs acting independently of aldosterone. Spironolactone and eplerenone are aldosterone antagonists, thereby inhibiting Na reabsorption and K loss through the blockade of aldosterone receptors in the DCT; these drugs are secreted from the peritubular capillaries.

A mineralocorticoid receptor antagonist (MRA or MCRA) or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at