Obinutuzumab vs rituximab

☑️@obinutuzumab_vs_ritu · 3769 subscribers · Content 18+ 🔞
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Actual: by T Berger 2024Introduction - The recent GALLIUM study showed an advantage of 7% in progression free survival in favor of obinutuzumab (G) vs. rituximab
4.9 rating 2025-04-24
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Obinutuzumab vs. rituximab in follicular lymphoma explained in Quick Take video:

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Obinutuzumab vs. rituximab in follicular lymphoma explained in Quick Take video:

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Our analysis shows that O-chemo was more costly ( 40,477 for obinutuzumab vs 25,503 for rituximab) but more effective, with expected OS prolongation of 0.97 years (14.31 LYs for obinutuzumab vs 13.35 for rituximab). This corresponds to a 0.88 QALY gain (12.55 QALYs for obinutuzumab vs 11.68 QALYs for rituximab).

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Obinutuzumab is different/superior to rituximab (chimeric) ofatumumab KidneyWk.

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However, results of rituximab and obinutuzumab should be interpreted with caution, taking into consideration that obinutuzumab is administered at higher doses compared to rituximab. Although some earlier clinical studies of rituximab were disappointing 45, 46, subsequent trials demonstrated that higher doses of rituximab were associated with

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by Y Chu Cited by 7vs rituximab. We hypothesize that obinutuzumab vs rituximab will significantly enhance in-vitro and in-vivo cytotoxicity against PMBL. PMBL

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Four RCTs with 3465 patients compared obinutuzumab with rituximab in induction therapy of CD20 B-NHL. Meta-analyses showed that compared with rituximab, obinutuzumab significantly prolonged

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by AS Freedman Cited by 1Outline Bendamustine plus rituximab R-CHOP Obinutuzumab-based regimens Lenalidomide plus rituximab or obinutuzumab.

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Obinutuzumab is a glycoengineered type II anti-CD20 monoclonal antibody (mAb), recognizing a unique CD20 extracellular membrane epitope with enhanced antibody dependent cellular cytotoxicity (ADCC) vs rituximab. We hypothesize that obinutuzumab vs rituximab will significantly enhance in-vitro and in-vivo cytotoxicity against PMBL. PMBL cells

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