Conversion to tadalafil resulted in significant improvement in patient ratings of therapy convenience. Conclusions: Transition of patients from sildenafil to tadalafil was usually well
The maximum dose utilized was 40.0 mg once daily. Patients who were transitioned from sildenafil to tadalafil had a direct conversion to a full 1.0 mg/kg daily dose (up to a maximum
This study assessed the safety and patient satisfaction with conversion from sildenafil to tadalafil. Methods: In this multicenter, prospective, 6-month study, patients with PAH were instructed to take their last dose of sildenafil in the evening and initiate tadalafil 40 mg/d the next morning. Patients completed the Treatment Satisfaction
This study assessed the safety and patient satisfaction with conversion from sildenafil to tadalafil.Methods: In this multicenter, prospective, 6-month study, patients with PAH were instructed to take their last dose of sildenafil in the evening and initiate tadalafil 40 mg/d the next morning.
Conversion to tadalafil resulted in significant improvement in patient ratings of therapy convenience. Conclusions: Transition of patients from sildenafil to tadalafil was usually well tolerated, with improved convenience and may enhance treatment satisfaction. Keywords sildenafil, tadalafil, switch, pulmonary arterial hypertension, patient
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Conversion from sildenafil to tadalafil: results from the sildenafil to tadalafil in pulmonary arterial hypertension (SITAR) study J Cardiovasc Pharmacol Ther . 2025 Nov;19(6): . doi: 10.1177/ .
This study assessed the safety and patient satisfaction with conversion from sildenafil to tadalafil.Methods: In this multicenter, prospective, 6-month study, patients with PAH were instructed to take their last dose of sildenafil in the evening and initiate tadalafil 40 mg/d the next morning.
Additionally, the mean half-life of sildenafil is approximately 4 h, with demonstrated improvement in EF for up to 8–12 h post-dose; conversely, the mean half-life of tadalafil is 17.5 h, with
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