Height drugs for people with noonan syndrome
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Turner syndrome. Noonan syndrome. Idiopathic short stature Concomitant administration of other treatments that may have an effect on growth
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Noonan syndrome is caused by mutations in certain genes that can be inherited from a parent who has an affected gene. It also can occur spontaneously in a child whose parents do not have an affected gene. One of several different genes may be involved. Noonan syndrome is relatively common, occurring in about 1 in 1,000 to 2,500 people.
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by JA Noonan 2024 Cited by 66Noonan syndrome patients at the start of therapy. BMI is not affected MeSH terms. Adiposity / drug effects; Adolescent; Adult; Body Height / drug effects
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The outcomes were changes in growth velocity (GV) and height standard deviation scores (SDS) for normal (height-CDC SDS) and Noonan standards (height-NS SDS). Results: The pretreatment chronological age was 10.3 3.5 years. Height-CDC SDS and height-NS SDS were -3.1 0.7 and -0.5 0.6, respectively.
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The Impact of Growth Hormone Therapy on Adult Height in Noonan Syndrome: A Systematic Review HUMAN growth hormone CHILDREN STATURE ANTHROPOMETRY NOONAN
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by A Libraro 2024 Cited by 9Keywords: Noonan Syndrome, growth, children, growth hormone treatment, adult height Height in Patients With PTPN11 Mutations Related to Noonan
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Long-term GH treatment improves adult height in children with Noonan syndrome with and without mutations in protein tyrosine phosphatase, non-receptor-type 11 Eur J Endocrinol . 2024 Sep;159(3): . doi: 10.1530/EJE- .
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Data are difficult to compare because of differing protocols and outcome criteria. In a report of final adult height of 73 patients with a clinical diagnosis of Noonan syndrome, 21 had an adult height in the normal range. 22 Analysis of data from 370 children with Noonan syndrome in the National Cooperative Growth Study 23 a post
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Medicine known as human growth hormone can sometimes help children reach a more normal height. Left untreated, the average adult height for men with Noonan syndrome is 162.5cm (5ft 3in) and for women is 153cm (5ft). Heart defects. Most children with Noonan syndrome will have some form of congenital heart disease. This is usually one of the
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