Bioavailability morphine

☑️@bioavailability_morp · 3074 subscribers · Content 18+ 🔞
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Actual: Morphine is metabolized to inactive morphine-3-glucuronide (60%) and to active morphine-6-glucuronide (10%). Morphine has an oral bioavailability of about 30% in adults. Morphine-6-glucuronide has an oral bioavailability of about 4%, but probably can be converted back to morphine in the infant's gut and absorbed as morphine.
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Oral diacetylmorphine (heroin) yields greater morphine bioavailability than oral morphine: bioavailability related to dosage and prior opioid exposure.

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Drug Levels. Morphine is metabolized to inactive morphine-3-glucuronide (60%) and to active morphine-6-glucuronide (10%). Morphine has an oral bioavailability of about 30% in adults. Morphine-6-glucuronide has an oral bioavailability of about 4%, but probably can be converted back to morphine in the infant's gut and absorbed as morphine.

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- SL bioavailability of morphine ranged Bioavailability of hydrophilic opioids (morphine, oxycodone, and hydromorphone) is much less.

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Morphine is metabolized to inactive morphine-3-glucuronide (60%) and to active morphine-6-glucuronide (10%). Morphine has an oral bioavailability of about 30% in adults. Morphine-6-glucuronide has an oral bioavailability of about 4%, but probably can be converted back to morphine in the infant's gut and absorbed as morphine.

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Morphine is metabolized to inactive morphine-3-glucuronide (60%) and to active morphine-6-glucuronide (10%). Morphine has an oral bioavailability of about 30% in adults. Morphine-6-glucuronide has an oral bioavailability of about 4%, but probably can be converted back to morphine in the infant's gut and absorbed as morphine.

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To determine the bioavailability of topically administered morphine, the absorption, distribution, and elimination pharmacokinetics of topically administered morphine must be referenced to the pharmacokinetics of morphine administered by a route for which 100% bioavailability can be assumed, such as subcutaneously administered morphine. 6

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Morphine is metabolized to inactive morphine-3-glucuronide (60%) and to active morphine-6-glucuronide (10%). Morphine has an oral bioavailability of about 30% in adults. Morphine-6-glucuronide has an oral bioavailability of about 4%, but probably can be converted back to morphine in the infant's gut and absorbed as morphine.

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Morphine has an oral bioavailability of about 30% in adults. Morphine-6-glucuronide has an oral bioavailability of about 4%, but probably can be converted back to morphine in the infant's gut and absorbed as morphine. The plasma clearance of morphine is prolonged in very young infants compared to older infants and children.

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Morphine is metabolized to inactive morphine-3-glucuronide (60%) and to active morphine-6-glucuronide (10%). Morphine has an oral bioavailability of about 30% in adults. Morphine-6-glucuronide has an oral bioavailability of about 4%, but probably can be converted back to morphine in the infant's gut and absorbed as morphine.

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